The transdermal route is widely used now days as it is convenient over the conventional dosage forms. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Niosomes can entrap both hydrophilic and lipophilic drugs and can prolong the circulation of the entrapped drug in body. Selection of surfactant should be done on the basis of hlb value.
Qushawy 1 1department of pharmaceutics, faculty of pharmacy and pharmaceutical industries, sinai university, elarish, north sinai, egypt. Formulation vitamin c using niosomes system span 80 in gel for increase stability and penetration in vitro pratiwi apridamayanti, nina listiyana, rise desnita of pharmacy, faculty of medicine, university of tanjungpura, pontianak jl. Targeted drug delivery can also be achieved using niosomes the drug is delivered directly to the body part where the therapeutic effect is required. Recent trends in niosome as vesicular drug delivery system japs.
Niosomes are vesicles composed of nonionic surfaceactive agent bilayers, which serve as novel drug delivery systems. The selfassembly of nonionic surfactant into vesicles was first reported in the seventies by researchers in the cosmetic industry. Skin is the main target of topical and transdermal preparations. Niosomes are made of nonionic surfactants and cholesterol. Niosomes are made up of uncharged single chain surfactant molecules. Preparation and characterization of giant niosomes masters thesis in nanotechnology maryam homaei department of microtechnology and nanoscience mc2 chalmers university of technology gothenburg, sweden 2016. Niosomes are formed mostly by cholesterol incorporation as an. Vesicular system such as liposomes, niosomes, transferosomes, pharmacosomes and ethosomes provide an alternative to improve the drug delivery. Niosomes and liposomes have similar application in drug delivery but chemically differ in structure units.
Niosomes, nonionic surfactant vesicles with lamellar structure which may be unilamellar and multilamellar serve to be efficient in providing these required advantages. What is the difference between liposomes and niosomes. They are functionally the same, have the same physical properties and act as amphiphilic vesicules. Development and characterization of niosomal drug delivery. April june 64 by which induces vesicle shape transformation. The result suggested that niosomes prepared were of uniform size and spherical in shape shown in fig. The first product niosome was introduced in 1987 by lancome a loreal company. Niosomes are formed on the admixture of nonionic surfactant of the alkyl or dialkylpolyglycerol ether class and cholesterol with subsequent hydration in. Niosomes and its application navneet kumar verma 1department of pharmacy, rameshwaram institute of technology and management lucknow, u. Niosomes were prepared by the thin film hydration method followed by gel permeation chromatography to obtain purified niosome suspensions. So niosomes can be used for the delivery of labile and sensitive drugs. The surfactants used and also the prepared niosomes are biodegradable, biocompatible and nonimmunogenic. Nowadays we better know vesicles have importance in. Sustained release of acyclovir from nanoliposomes and.
Niosomes are microscopic in size and their size lies in the nanometric scale. Stability studies on piroxicam encapsulated niosomes. Inhalable cationic niosomes of curcumin enhanced drug delivery and apoptosis in lung cancer cells kiran jyoti1, ravi shankar pandey2, jitender madan1, upendra kumar jain1 1department of pharmaceutics, chandigarh college of pharmacy, mohali panjab india. The handshaking method is a simple and efficient technique for designing functional niosomes for hydrophobic or amphiphilic drugs. In niosomes, the vesicles forming amphiphilic is a nonionic surfactant such as span 60 which is usually stabilized by addition of. Controlled release drug products are highly used for the formation and maintenance of whichever concentration needed at target site for longer duration of time, and this drug targeting method named as niosomes. A diverse range of materials have been used to form niosomes such as sucrose ester surfactants and polyoxyethylene alkyl ether surfactants, alkyl ester, alkyl amides, fatty acids and.
Research article formulation and invitro evaluation of. Transdermal route bypasses the gi tract hence avoiding the gastric irritation, reduces number of doses, improved patience compliance, enhanced bioavailability and can maintain suitable plasma concentration 1 controlled release dosage forms are widely used in now a days. Niosomes and liposomes are equiactive in drug delivery potential and both increase drug efficacy as compared with that of free drug. Nonionic surfactant vesicles niosomes were formulated with an aim of enhancing the oral bioavailability of tenofovir disoproxil fumarate tdf. The average vesicular size of niosomes of all the batches was measured in the range of 4.
Drug delivery through niosomes is one of the approaches to achieve localised drug action in regard to their size and low penetrability through epithelium and connective tissue, which keeps the drug localised at the site of administration. Niosomes have more penetrating capability than the previous preparations of emulsions. The average vesicle size of the prepared niosomes was measured by using optical microscope vaiseshika 7001ims and the vesicle size distribution studies were performed on the optimized batches by measuring the size of randomly selected 100 niosomes vesicles from each formulation. Nonionic surfactant vesicles niosomes result from the organized assembly of sufficiently insoluble surfactants in aqueous media. Since then an ever increasing interest has been exhibited on the application of niosomes in the field of pharmaceutics, cosmetics and food industry, leading to the publication of more than 1200 research articles, about 200 patents and 6 clinical trials from 1980. The vesicles were discrete and separate with no aggregation or agglomeration figure 1.
However, the materials used to prepare niosomes confer better stability on them. Niosomes are formed mostly by nonionic surfactant and cholesterol incorporation as an excipient. Niosomes is a container for drug molecules with an extensive range of solubilities owing to existence of hydrophilic, lipophilic, and amphiphilic moieties in the constitution. The release of drug from niosomes is determined using the membrane diffusion technique. Niosomes are osmotically active and stable and also increase the stability of the entrapped drug. Formulation and evaluation of lansoprazole niosome naresh ahuja, vipin saini, vijay kumar bishnoi, atul garg, monika hisoria, joyati sharma and kunal nepali department of pharmaceutics, bharti institute of pharmaceutical sciences, sriganganagar335001 raj. Contents of the powerpoint on niosomes drug delivery systems include. Niosomes as carrier in dermal drug delivery 143 figure 2. Niosomes as carrier in dermal drug delivery intechopen. Niosomes have numerous advantages over other drug delivery systems.
Inhalable cationic niosomes of curcumin enhanced drug. Transdermal route bypasses the gi tract hence avoiding the gastric irritation, reduces number of doses, improved patience compliance, enhanced bioavailability and can maintain suitable plasma concentration 1. Piroxicam which was chosen as the model drug was loaded to niosomes. They are being used in topical and transdermal products both contaning hydrophobic and hydrophillic drugs. Niosomes are known to be superior to liposomes because of their higher chemical stability of surfactants than lipids. Aceclofenac is a drug with narrow therapeutic index and short biological halflife. Localization of drugs encapsulated in niosomes is utilized to treat tumors known to metastasize to the liver and spleen. Jun 09, 2010 the uptake of niosomes is controlled by circulating serum factors called opsonins, which mark the niosomes for clearance while delivering the cargo to the antigen presenting cells. Localization of drugs encapsulated in niosomes is utilized to treat tumors known to.
The low cost of ingredients and manufacture, possibility of largescale production, stability and the resultant ease of storage of niosomes have led to the exploitation of these nano carriers as alternatives to other micro and nanoencapsulation technologies. During the past decade formulation of vesicles as a tool to improve drug delivery, has created a lot of interest amongst the scientist working in the area of drug delivery systems. Niosomes can be used for oral delivery of drug thus protecting it from the hostile environment of the git and targeting to re. Niosomes may be unilamellar or multilamellar depending on the method used to prepare them.
Oct 30, 2012 advantages of niosomes targeted drug delivery can be achieved using niosomes the drug is delivered directly to the body part where the therapeutic effect is required reduced dose is required to achieve the desired effect subsequent decrease in the side effects the therapeutic efficacy of the drugs is improved by reducing the clearance rate. The uptake of niosomes is controlled by circulating serum factors called opsonins, which mark the niosomes for clearance while delivering the cargo to the antigen presenting cells. Recent trends in niosome as vesicular drug delivery system. Carriers for topical and transdermal drug delivery adapted from reference venuganti et al. Structure of niosomes niosomes are microscopic lamellar structures which are formed on the admixture of nonionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. The effort was made to study in vitro whether acyclovirloaded nanovesicles could sustain the release of the drug by increasing residence time and.
Asian journal of research in biological and pharmaceutical sciences. The diameter of the formulated niosomes was found to be in the range of 12. Niosomes constitute of nonionic surfactant whereas liposomes comprise of phospholipids khan et al. Minoxidil niosomes were prepared using thin film hydration method. The advantages of using niosomes in cosmetic and skin care applications include. Formulation and optimization of zidovudine niosomes. Niosomes are nonionic surfactant based unilamellar or multilamellar bilayer vesicles up on hydration of non ionic surfactants with or without incorporation cholesterol. September october 445 niosomes are microscopic lamellar structure of size range between 10nm and consists of. Dec 26, 2010 niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle.
Formulation and characterization of drug loaded nonionic. The vesicle is composed of a bilayer of nonionic surface active agents and hence the name niosomes. Niosomes are vesicles of nonionic surfactant for example, alkyl ester and alkyl ether and cholesterol that act as a carrier for amphiphilic and. They are structurally similar to liposomes in having a bilayer, however, the materials used to prepare niosomes make them more. However, stability issue is not clear yet and is a serious drawback for niosomes. Niosomes are nonionic surfactant vesicle composed of cholesterol and alkyl or dialkyl polyglycerol ether group. This research article focuses on the concept of niosomes, advantages and disadvantages, composition, method of preparation, factors that influence the niosomal formulation and characterization, application of niosomes.
Niosomes are used for better targeting of the drug at appropriate tissue destination. Asian journal of research in biological and pharmaceutical. International journal of pharmaceutics formulation and. The niosomes have amphiphillic bilayer structure in a way that polar region is. Vesicular system, niosomes, nonionic surfactant, cholesterol. Niosomes possess a bilayer structure, which is similar to liposomes. Nonsonicated niosomes were in the size range of 23. Effect of charged and nonionic membrane additives on. In this study, the stability of niosomes was the center of interest. Paclitaxelloaded niosomes for intravenous administration. Evaluations of quality by design qbd elements impact for. In this study, niosomes were prepared by reverse phase evaporation rev method 14,15. Niosomes are nonionicbased surfactant unilamellar or multilamellar vesicles with a bilayer structure that have been used for around 40 years as drug delivery systems for different applications.
Development and characterization of niosomal drug delivery of. Niosomes are unilamellar or multilamellar vesicles. Design, formulation, and evaluation of piroxicam niosomal gel ahmed m. Niosomes are prepared from uncharged single chain surfactant and cholesterols. Niosomes or non ionic surfactant vesicles are formed from self assembly of hydrated surfactant. Niosomes are biodegradable, biocompatible, and nonimmunogenic. The present study was designed to develop and compare acyclovir containing nanovesicular liposomes and niosomes based on cholesterol, soya l. Liposomes were first in such type of delivery systems but it was not so successful due to their numerous drawbacks. Niosomes are nonionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. Niosomes are a novel surfactantbased delivery system that may be used to deliver desoximetasone via topical product application in order to. Niosomes are a novel drug delivery system, in which the medication is encapsulated in a vesicle. Structure of niosomes niosomes are microscopic lamellar structures which are formed on the admixture of nonionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in. Niosome using span60 as surfactant, image from niosome liposome are made of phospholipids, th. Niosomes or non ionic surfactant vesicles are formed from self assembly of hydrated surfactant monomers.
As hydrophilic lipophilic balance hlb is a good indicator of the vesicle forming ability of any surfactant, hlb number in between 4 and 8 was found to be compatible with. Niosome definition of niosome by medical dictionary. Niosomes are one of the promising drug carriers that have a bilayer structure and are formed by selfassociation of nonionic surfactants and cholesterol in an aqueous phase. Vesicular drug delivery system are novel means to improve the bioavailability of the encapsulated drug along with numerous advantages over conventional drug delivery systems. Elliott abstract the research presented in this dissertation describes the creation and characterization of a novel antibodyvesicle conjugate modified with polyethylene glycol peg that possesses enhanced binding to and uptake by inflammationactivated. Niosomes mainly contains following types of components. Advantages of niosomes targeted drug delivery can be achieved using niosomes the drug is delivered directly to the body part where the therapeutic effect is required reduced dose is required to achieve the desired effect subsequent decrease in the side effects the therapeutic efficacy of the drugs is improved by reducing the clearance rate. Jan, 2014 contents of the powerpoint on niosomes drug delivery systems include.
They are functionally the same, have the same physical properties and act. From each batch about 100 niosomes were measured for the diameter. All content in this area was uploaded by vishal sanklecha on feb 02, 2019. Formulation and evaluation pranshu tangri1, shaffi khurana1 ditfaculty of pharmacy mussoorie diversion road, bhagwantpura, dehradun, uttarakhand248001 abstract niosomes are nonionic surfactant vesicles obtained on hydration of synthetic nonionic surfactants, with or without incorporation of cholesterol or other lipids. Niosomes serve as drug depots in the body which release the drug in a controlled manner through its bilayer providing sustained release of the enclosed drug. The niosomes are very small, and microscopic in size. Niosomes are nonionic surfactant vesicles having a. Niosomes are formed on the admixture of nonionic surfactant of the alkyl or dialkylpolyglycerol ether class and cholesterol with subsequent hydration in aqueous media. Pharmacokinetic study of niosomeloaded insulin in diabetic rats. Accurately weighed quantities of the surfactant brijtm or spantm. International journal of research in pharmaceutical and nano sciences. Niosomes are now widely studied as an alternative to liposomes. Niosomes, an alternative for liposomal delivery plos. Design, formulation, and evaluation of piroxicam niosomal gel.
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